Anti-ABCA5 antibody (1540-1642 aa) (STJ13100642)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 1540-1642 of human ABCA5 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCA5 (1540-1642 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCA5 |
| Gene ID | 23461 |
| Uniprot ID | ABCA5_HUMAN |
| Immunogen | A synthetic peptide from aa region 1540-1642 of human ABCA5 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 1540-1642 aa |
| Specificity | Specific for ABCA5. |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes. |
| Protein Name | Cholesterol Transporter Abca5Atp-Binding Cassette Sub-Family A Member 5 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinLysosome MembraneLate Endosome MembraneCell MembraneLocalized At Cell Membrane Under High Cholesterol Levels |
| Alternative Antibody Names | Anti-Cholesterol Transporter Abca5 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 5 antibodyAnti-ABCA5 antibodyAnti-KIAA1888 antibody |
Information sourced from Uniprot.org