Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-ABCA1 (1170-1350) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ABCA1 |
Gene ID: | 19 |
Uniprot ID: | ABCA1_HUMAN |
Immunogen Region: | 1170-1350 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1 (NP_005493.2). |
Immunogen Sequence: | DHESDTLTIDVSAISNLIRK HVSEARLVEDIGHELTYVLP YEAAKEGAFVELFHEIDDRL SDLGISSYGISETTLEEIFL KVAEESGVDAETSDGTLPAR RNRRAFGDKQSCLRPFTEDD AADPNDSDIDPESRETDLLS GMDGKGSYQVKGWKLTQQQF VALLWKRLLIARRSRKGFFA Q |
Tissue Specificity | Widely expressed, but most abundant in macrophages. |
Post Translational Modifications | Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. |
Protein Name | Phospholipid-Transporting Atpase Abca1 Atp-Binding Cassette Sub-Family A Member 1 Atp-Binding Cassette Transporter 1 Abc-1 Atp-Binding Cassette 1 Cholesterol Efflux Regulatory Protein |
Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-5682113 Reactome: R-HSA-8963896 Reactome: R-HSA-9029569 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endosome |
Alternative Antibody Names | Anti-Phospholipid-Transporting Atpase Abca1 antibody Anti-Atp-Binding Cassette Sub-Family A Member 1 antibody Anti-Atp-Binding Cassette Transporter 1 antibody Anti-Abc-1 antibody Anti-Atp-Binding Cassette 1 antibody Anti-Cholesterol Efflux Regulatory Protein antibody Anti-ABCA1 antibody Anti-ABC1 antibody Anti-CERP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance