|STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
|Rabbit polyclonal antibody anti-Phospholipid-transporting ATPase ABCA1 (1112-1180 aa) is suitable for use in Western Blot and ELISA research applications.
|Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
|The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
|WB 1:500-2000ELISA 1:5000-20000
|Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
|ABCA1 Polyclonal Antibody detects endogenous levels of protein.
|Synthesized peptide derived from part of the human protein at the amino acid range 1112-1180
| Post Translational Modifications
| Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane.
| Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain.
| Protein Name
| Phospholipid-Transporting Atpase Abca1Atp-Binding Cassette Sub-Family A Member 1Atp-Binding Cassette Transporter 1Abc-1Atp-Binding Cassette 1Cholesterol Efflux Regulatory Protein
| Database Links
| Reactome: R-HSA-1989781Reactome: R-HSA-5682113Reactome: R-HSA-8963896Reactome: R-HSA-9029569
| Cellular Localisation
| Cell MembraneMulti-Pass Membrane ProteinEndosome
| Alternative Antibody Names
| Anti-Phospholipid-Transporting Atpase Abca1 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 1 antibodyAnti-Atp-Binding Cassette Transporter 1 antibodyAnti-Abc-1 antibodyAnti-Atp-Binding Cassette 1 antibodyAnti-Cholesterol Efflux Regulatory Protein antibodyAnti-ABCA1 antibodyAnti-ABC1 antibodyAnti-CERP antibody
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance