||WB, IHC-P, IF-P, ELISA
||Human, Rat, Mouse
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Alpha-2-Macroglobulin (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||A2M polyclonal antibody (Alpha-2-Macroglobulin) binds to endogenous Alpha-2-Macroglobulin at the amino acid region Internal.
||The antiserum was produced against synthesized peptide derived from the Internal region of human A2M at amino acid range 871-920
| Function || Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name || Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links || Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
| Cellular Localisation || Secreted |
| Alternative Antibody Names || Anti-Alpha-2-Macroglobulin antibodyAnti-Alpha-2-M antibodyAnti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibodyAnti-A2M antibodyAnti-CPAMD5 antibodyAnti-FWP007 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance