| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-14-3-3 alpha+beta is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | SM5110 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | IHC/IF (H, M, R) 1:500-1:1000/1:500-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Ywhab |
| Gene ID: | 54401 |
| Uniprot ID: | 1433B_MOUSE |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse 14-3-3 alpha + beta |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Protein Name | 14-3-3 Protein Beta/AlphaProtein Kinase C Inhibitor Protein 1Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed |
| Database Links | Reactome: R-MMU-111447Reactome: -MMU-165159Reactome: -MMU-166208Reactome: -MMU-170968Reactome: -MMU-2028269Reactome: -MMU-392517Reactome: -MMU-450385Reactome: -MMU-450513Reactome: -MMU-5625740Reactome: -MMU-5628897Reactome: -MMU-5673000Reactome: -MMU-5674135Reactome: -MMU-5675221Reactome: -MMU-75035Reactome: -MMU-9614399 |
| Cellular Localisation | CytoplasmMelanosome |
| Alternative Antibody Names | Anti-14-3-3 Protein Beta/Alpha antibodyAnti-Protein Kinase C Inhibitor Protein 1 antibodyAnti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibodyAnti-Ywhab antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
