| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-14-3-3 alpha+beta is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | SM5110 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | IHC/IF (H, M, R) 1:500-1:1000/1:500-1:1000 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Ywhab |
| Gene ID: | 54401 |
| Uniprot ID: | 1433B_MOUSE |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse 14-3-3 alpha + beta |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Protein Name | 14-3-3 Protein Beta/Alpha Protein Kinase C Inhibitor Protein 1 Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed |
| Database Links | Reactome: R-MMU-111447 Reactome: -MMU-165159 Reactome: -MMU-166208 Reactome: -MMU-170968 Reactome: -MMU-2028269 Reactome: -MMU-392517 Reactome: -MMU-450385 Reactome: -MMU-450513 Reactome: -MMU-5625740 Reactome: -MMU-5628897 Reactome: -MMU-5673000 Reactome: -MMU-5674135 Reactome: -MMU-5675221 Reactome: -MMU-75035 Reactome: -MMU-9614399 |
| Cellular Localisation | Cytoplasm Melanosome |
| Alternative Antibody Names | Anti-14-3-3 Protein Beta/Alpha antibody Anti-Protein Kinase C Inhibitor Protein 1 antibody Anti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibody Anti-Ywhab antibody |
Information sourced from Uniprot.org
