| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-alpha Actinin 4 Blocking Peptide is synthetically produced from the 60-110 sequence and is suitable for use in western blot applications. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ACTN4 |
| Gene ID: |
81 |
| Uniprot ID: |
ACTN4_HUMAN |
| Immunogen Region: |
60-110 |
| Immunogen: |
Synthetic peptide taken within amino acid region 60-110 on human alpha-actinin-4 protien. Phosphorylated Serine-99 residue. |
| Tissue Specificity | Widely expressed. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. |
| Peptide Name | Alpha-Actinin-4Non-Muscle Alpha-Actinin 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753 |
| Cellular Localisation | NucleusCytoplasmCell JunctionCytoskeletonStress FiberPerinuclear RegionLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasExpressed In The Perinuclear Rim And Manchette Structure In Early Elongating Spermatids During SpermiogenesisNuclear Translocation Can Be Induced By The Pi3 Kinase Inhibitor Wortmannin Or By Cytochalasin DExclusively Localized In The Nucleus In A Limited Number Of Cell Lines (Breast Cancer Cell Line Mcf-7Oral Floor Cancer Imc-2And Bladder Cancer Ku-7) |
| Alternative Peptide Names | Alpha-Actinin-4 proteinNon-Muscle Alpha-Actinin 4 proteinACTN4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
