Active Mouse CSF-1/M-CSF protein (Recombinant) (C-His) (STJP002734)

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STJP002734
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: 1.Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 0.1-0.4 ng/mL, corresponding to a specific activity of 2.5×106-1.0×107units/m
Gene Symbol: Csf1
Gene ID: 12977
Uniprot ID: CSF1_MOUSE
Immunogen Region: Met1-Glu262
Immunogen: Active Recombinant Mouse CSF-1/M-CSF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu262) of mouse M-CSF/CSF-1 (Accession #NP_031804.3.) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: MTARGAAGRCPSSTWLGSRL LLVCLLMSRSIAKEVSEHCS HMIGNGHLKVLQQLIDSQME TSCQIAFEFVDQEQLDDPVC YLKKAFFLVQDIIDETMRFK DNTPNANATERLQELSNNLN SCFTKDYEEQNKACVRTFHE TPLQLLEKIKNFFNETKNLL EKDWNIFTKNCNNSFAKCSS RDVVTKPDCNCLYPKATPSS DPASASPHQPPAPSMAPLAG LAWDDSQRTEGSSLLPSEL
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Protein Name Macrophage Colony-Stimulating Factor 1
Csf-1
Mcsf
Proteoglycan Macrophage Colony-Stimulating Factor
Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit
Database Links Reactome: R-MMU-381426
Reactome: -MMU-449836
Reactome: -MMU-8957275
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Macrophage Colony-Stimulating Factor 1: Secreted
Extracellular Space
Alternative Protein Names Macrophage Colony-Stimulating Factor 1 protein
Csf-1 protein
Mcsf protein
Proteoglycan Macrophage Colony-Stimulating Factor protein
Pg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit protein
Csf1 protein
Csfm protein

Information sourced from Uniprot.org

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