| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
YME1L1 Blocking Peptide for STJ503569 is synthetically produced from the 720-773 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
YME1L1 |
| Gene ID: |
10730 |
| Uniprot ID: |
YMEL1_HUMAN |
| Immunogen Region: |
720-773 |
| Specificity: |
This blocking peptide is recommended for use in combination with YME1L1 antibody, STJ503569 |
| Immunogen: |
Synthetic peptide taken within amino acid region 720-773 on human ATP-dependent metalloprotease YME1L1 protein. |
| Tissue Specificity | High expression in cardiac and skeletal muscle mitochondria. |
| Post Translational Modifications | Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. Degraded in an OMA1-dependent manner in response to oxidative stress. |
| Function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome. Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition. Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Mediates degradation of TIMM17A downstream of the integrated stress response (ISR). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide. |
| Peptide Name | Atp-Dependent Zinc Metalloprotease Yme1l1Atp-Dependent Metalloprotease Ftsh1Meg-4Presenilin-Associated MetalloproteasePampYme1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8949664Reactome: R-HSA-9837999Reactome: R-HSA-9840373 |
| Cellular Localisation | Mitochondrion Inner MembraneMitochondrion |
| Alternative Peptide Names | Atp-Dependent Zinc Metalloprotease Yme1l1 proteinAtp-Dependent Metalloprotease Ftsh1 proteinMeg-4 proteinPresenilin-Associated Metalloprotease proteinPamp proteinYme1-Like Protein 1 proteinYME1L1 proteinFTSH1 proteinYME1L proteinUNQ1868 proteinPRO4304 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
