| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | XTP4 Blocking Peptide is synthetically produced from the 80-130 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | MIEN1 |
| Gene ID: | 84299 |
| Uniprot ID: | MIEN1_HUMAN |
| Immunogen Region: | 80-130 |
| Immunogen: | Synthetic peptide taken within amino acid region 80-130 on human XTP4 protein. |
| Tissue Specificity | Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level). |
| Post Translational Modifications | Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation. |
| Function | Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. |
| Peptide Name | Migration And Invasion Enhancer 1 Hbv X-Transactivated Gene 4 Protein Hbv Xag-Transactivated Protein 4 Protein C35 |
| Cellular Localisation | Cytoplasm Cytosol Cell Membrane Lipid-Anchor Cytoplasmic Side Concentrates At The Leading Edge Of Migrating Cells Localizes Outside Membrane Raft Regions |
| Alternative Peptide Names | Migration And Invasion Enhancer 1 protein Hbv X-Transactivated Gene 4 Protein protein Hbv Xag-Transactivated Protein 4 protein Protein C35 protein MIEN1 protein C17orf37 protein RDX12 protein XTP4 protein |
Information sourced from Uniprot.org