Wilms Tumor Protein Positive Control for STJ505992 peptide (STJ505761)

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STJ505761-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Wilms Tumor Protein Positive Control for STJ505992 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: WT1
Gene ID: 7490
Uniprot ID: WT1_HUMAN
Specificity: This is positive control is recommended for use in combination with Wilms Tumor Protein antibody STJ505992.
Immunogen: Wilms tumor protein WT1
Tissue Specificity Expressed in the kidney and a subset of hematopoietic cells.
Function Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Peptide Name Wilms Tumor Protein
Wt33
Database Links Reactome: R-HSA-9690406
Reactome: R-HSA-9831926
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
Isoforms Lacking The Kts Motif Have A Diffuse Nuclear Location
Shuttles Between Nucleus And Cytoplasm
Isoform 1: Nucleus Speckle
Isoform 4: Nucleus
Nucleoplasm
Alternative Peptide Names Wilms Tumor Protein protein
Wt33 protein
WT1 protein

Information sourced from Uniprot.org

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