| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
WDR5 Positive Control for STJ503519 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
WDR5 |
| Gene ID: |
11091 |
| Uniprot ID: |
WDR5_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with WDR5 antibody STJ503519. |
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Peptide Name | Wd Repeat-Containing Protein 5Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9733709Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Wd Repeat-Containing Protein 5 proteinBmp2-Induced 3-Kb Gene Protein proteinWDR5 proteinBIG3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
