| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Visfatin Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | NAMPT |
| Gene ID: | 10135 |
| Uniprot ID: | NAMPT_HUMAN |
| Tissue Specificity | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. |
| Function | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| Peptide Name | Nicotinamide Phosphoribosyltransferase Namprtase Nampt Pre-B-Cell Colony-Enhancing Factor 1 Pre-B Cell-Enhancing Factor Visfatin |
| Database Links | Reactome: R-HSA-1368108 Reactome: R-HSA-197264 Reactome: R-HSA-9768919 |
| Cellular Localisation | Nucleus Cytoplasm Secreted Under Non-Inflammatory Conditions Visfatin Predominantly Exhibits A Granular Pattern Within The Nucleus Secreted By Endothelial Cells Upon Il-1beta Stimulation Abundantly Secreted In Milk Reaching 100-Fold Higher Concentrations Compared To Maternal Serum |
| Alternative Peptide Names | Nicotinamide Phosphoribosyltransferase protein Namprtase protein Nampt protein Pre-B-Cell Colony-Enhancing Factor 1 protein Pre-B Cell-Enhancing Factor protein Visfatin protein NAMPT protein PBEF protein PBEF1 protein |
Information sourced from Uniprot.org