Applications: |
WB |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
TMC2 Positive Control for STJ503321 is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
Dilution Range: |
WB: 1:2, 500-1:5, 000 |
Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: |
TMC2 |
Gene ID: |
117532 |
Uniprot ID: |
TMC2_HUMAN |
Specificity: |
This is positive control is recommended for use in combination with TMC2 antibody STJ503321. |
Immunogen: |
Purified Transmembrane channel-like protein 2. |
Tissue Specificity | Detected in fetal cochlea. |
Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear. |
Peptide Name | Transmembrane Channel-Like Protein 2Transmembrane Cochlear-Expressed Protein 2 |
Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells And Plasma Membranes Of Cuticular Plates |
Alternative Peptide Names | Transmembrane Channel-Like Protein 2 proteinTransmembrane Cochlear-Expressed Protein 2 proteinTMC2 proteinC20orf145 proteinUNQ907 proteinPRO1928 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance