TMC2 Positive Control for STJ503321 peptide (STJ505688)

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STJ505688-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TMC2 Positive Control for STJ503321 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TMC2
Gene ID: 117532
Uniprot ID: TMC2_HUMAN
Specificity: This is positive control is recommended for use in combination with TMC2 antibody STJ503321.
Immunogen: Purified Transmembrane channel-like protein 2.
Tissue Specificity Detected in fetal cochlea.
Function Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear.
Peptide Name Transmembrane Channel-Like Protein 2
Transmembrane Cochlear-Expressed Protein 2
Database Links Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Localized To The Stereocilia Tips Of The Cochlear Hair Cells And Plasma Membranes Of Cuticular Plates
Alternative Peptide Names Transmembrane Channel-Like Protein 2 protein
Transmembrane Cochlear-Expressed Protein 2 protein
TMC2 protein
C20orf145 protein
UNQ907 protein
PRO1928 protein

Information sourced from Uniprot.org

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