| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TMC2 Blocking Peptide for STJ503322 is synthetically produced from the 850-906 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TMC2 |
| Gene ID: |
117532 |
| Uniprot ID: |
TMC2_HUMAN |
| Immunogen Region: |
850-906 |
| Specificity: |
This blocking peptide is recommended for use in combination with TMC2 antibody, STJ503322 |
| Immunogen: |
Synthetic peptide taken within amino acid region 850-906 on human Transmembrane channel-like protein 2. |
| Tissue Specificity | Detected in fetal cochlea. |
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear. |
| Peptide Name | Transmembrane Channel-Like Protein 2Transmembrane Cochlear-Expressed Protein 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells And Plasma Membranes Of Cuticular Plates |
| Alternative Peptide Names | Transmembrane Channel-Like Protein 2 proteinTransmembrane Cochlear-Expressed Protein 2 proteinTMC2 proteinC20orf145 proteinUNQ907 proteinPRO1928 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
