| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TIPIN Blocking Peptide for STJ503264 is synthetically produced from the 240-270 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TIPIN |
| Gene ID: |
54962 |
| Uniprot ID: |
TIPIN_HUMAN |
| Immunogen Region: |
240-270 |
| Specificity: |
This blocking peptide is recommended for use in combination with TIPIN antibody, STJ503264 |
| Immunogen: |
Synthetic peptide taken within amino acid region 240-270 on mouse TIPIN protein. |
| Function | Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. |
| Peptide Name | Timeless-Interacting Protein |
| Database Links | Reactome: R-HSA-5693607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Peptide Names | Timeless-Interacting Protein proteinTIPIN protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
