Themis Positive Control peptide (STJ505196)

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STJ505196-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Themis Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: THEMIS
Gene ID: 387357
Uniprot ID: THMS1_HUMAN
Post Translational Modifications Phosphorylated on Tyr residues quickly after TCR stimulation.
Function Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Peptide Name Protein Themis
Thymocyte-Expressed Molecule Involved In Selection
Cellular Localisation Cytoplasm
Nucleus
Alternative Peptide Names Protein Themis protein
Thymocyte-Expressed Molecule Involved In Selection protein
THEMIS protein
C6orf190 protein
C6orf207 protein

Information sourced from Uniprot.org

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