| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | TGM1 Positive Control for STJ503239 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:450 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | F13a1 |
| Gene ID: | 74145 |
| Uniprot ID: | F13A_MOUSE |
| Specificity: | This is positive control is recommended for use in combination with TGM1 antibody STJ503239. |
| Post Translational Modifications | The activation peptide is released by thrombin. |
| Function | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Peptide Name | Coagulation Factor Xiii A Chain Coagulation Factor Xiiia Protein-Glutamine Gamma-Glutamyltransferase A Chain Transglutaminase A Chain |
| Database Links | Reactome: R-MMU-114608 Reactome: -MMU-140875 |
| Cellular Localisation | Cytoplasm Secreted Secreted Into The Blood Plasma Cytoplasmic In Most Tissues But Also Secreted In The Blood Plasma |
| Alternative Peptide Names | Coagulation Factor Xiii A Chain protein Coagulation Factor Xiiia protein Protein-Glutamine Gamma-Glutamyltransferase A Chain protein Transglutaminase A Chain protein F13a1 protein F13a protein |
Information sourced from Uniprot.org