| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TESK1 Positive Control for STJ506188 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TESK1 |
| Gene ID: |
7016 |
| Uniprot ID: |
TESK1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with TESK1 antibody STJ506188. |
| Post Translational Modifications | Autophosphorylated on serine and tyrosine residues. |
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis. |
| Peptide Name | Dual Specificity Testis-Specific Protein Kinase 1Testicular Protein Kinase 1 |
| Database Links | Reactome: R-HSA-446388 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionLamellipodiumColocalizes With Spry4 In Vesicular Spots In The CytoplasmLocalized To F-Actin-Rich Lamellipodia At The Cell Periphery Following Fibronectin-Mediated Cell Adhesion Of Schwann Cells |
| Alternative Peptide Names | Dual Specificity Testis-Specific Protein Kinase 1 proteinTesticular Protein Kinase 1 proteinTESK1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
