| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Phospho-STAT6 Blocking Peptide is synthetically produced from the 610-660 sequence and is suitable for use in western blot applications. |
| Dilution Range: | WB: 1:2, 500-1:5, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | STAT6 |
| Gene ID: | 6778 |
| Uniprot ID: | STAT6_HUMAN |
| Immunogen Region: | 610-660 |
| Immunogen: | Synthetic peptide taken within amino acid region 610-660 on human Phospho-specific Signal transducer and activator of transcription 6 protein. Phosphorylated Tyrosine 641 residue. |
| Post Translational Modifications | Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. Mono-ADP-ribosylated by PARP14. |
| Function | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. |
| Peptide Name | Signal Transducer And Activator Of Transcription 6 Il-4 Stat |
| Database Links | Reactome: R-HSA-186763 Reactome: R-HSA-3249367 Reactome: R-HSA-6785807 |
| Cellular Localisation | Cytoplasm Nucleus Translocated Into The Nucleus In Response To Phosphorylation |
| Alternative Peptide Names | Signal Transducer And Activator Of Transcription 6 protein Il-4 Stat protein STAT6 protein |
Information sourced from Uniprot.org