| Short Description : | SESN3 Blocking Peptide for STJ502958 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SESN3 |
| Gene ID: | 143686 |
| Uniprot ID: | SESN3_HUMAN |
| Immunogen: | Synthetic peptide taken within amino acid region 1-50 on SESN3 protein. |
| Immunogen Region: | 1-50 |
| Specificity: | This blocking peptide is recommended for use in combination with SESN3 antibody, STJ502958 |
| Function | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. |
| Peptide Name | Sestrin-3 |
| Database Links | Reactome: R-HSA-5628897 |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Sestrin-3 proteinSESN3 proteinSEST3 protein |
Information sourced from Uniprot.org