| Short Description : | SERINC5 Positive Control for STJ502941 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | WB: 1:500 |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Specificity: | This is positive control is recommended for use in combination with SERINC5 antibody STJ502941. |
| Background | Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed:26416733, PubMed:26416734). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). |
Information sourced from Uniprot.org