Septin 2 Blocking Peptide peptide (STJ504897)

SKU:
STJ504897-250

£289.50
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Septin 2 Blocking Peptide is synthetically produced from the 270-320 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SEPTIN2
Gene ID: 4735
Uniprot ID: SEPT2_HUMAN
Immunogen Region: 270-320
Immunogen: Synthetic peptide taken within amino acid region 270-320 on human Septin-2 protein.
Tissue Specificity Widely expressed. Up-regulated in liver cancer.
Function Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Peptide Name Septin-2
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 5
Nedd-5
Database Links Reactome: R-HSA-5620912
Cellular Localisation Cytoplasm
Cytoskeleton
Spindle
Chromosome
Centromere
Kinetochore
Cleavage Furrow
Midbody
Cell Cortex
Cell Projection
Cilium Membrane
Cilium
Flagellum
In Metaphase Cells
Localized Within The Microtubule Spindle
At The Metaphase Plate
In Close Apposition To The Kinetochores Of The Congressed Chromosomes
In Cells Undergoing Cytokinesis
Localized To The Midbody
The Ingressing Cleavage Furrow
And The Central Spindle
During Bacterial Infection
Displays A Collar Shape Structure Next To Actin At The Pole Of Invading Bacteria
In Epithelial Cells
Colocalizes With Polyglutamylated Tubulin Around The Trans-Golgi Network
As Well As Juxatnuclear And Proximal Golgi Apparatus
Localizes At The Base Of The Cilia Near The Morphological Distinction Between The Cilia And Plasma Membranes
Found In The Sperm Annulus
Alternative Peptide Names Septin-2 protein
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 5 protein
Nedd-5 protein
SEPTIN2 protein
DIFF6 protein
KIAA0158 protein
NEDD5 protein
SEPT2 protein

Information sourced from Uniprot.org

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