| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SATB2 Positive Control for STJ507822 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SATB2 |
| Gene ID: |
23314 |
| Uniprot ID: |
SATB2_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with SATB2 antibody STJ507822. |
| Post Translational Modifications | Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity. |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. |
| Peptide Name | Dna-Binding Protein Satb2Special At-Rich Sequence-Binding Protein 2 |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus Matrix |
| Alternative Peptide Names | Dna-Binding Protein Satb2 proteinSpecial At-Rich Sequence-Binding Protein 2 proteinSATB2 proteinKIAA1034 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
