| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | RNase H1 Positive Control for STJ506225 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | RNASEH1 |
| Gene ID: | 246243 |
| Uniprot ID: | RNH1_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with RNase H1 antibody STJ506225. |
| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II. |
| Peptide Name | Ribonuclease H1Rnase H1Ribonuclease H Type Ii |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Ribonuclease H1 proteinRnase H1 proteinRibonuclease H Type Ii proteinRNASEH1 proteinRNH1 protein |
Information sourced from Uniprot.org