RIC8A Positive Control for STJ502779 peptide (STJ505092)
SPECIFICATIONS
General Information
| Short Description | RIC8A Positive Control for STJ502779 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:250 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | RIC8A |
| Gene ID | 60626 |
| Uniprot ID | RIC8A_HUMAN |
| Specificity | This is positive control is recommended for use in combination with RIC8A antibody STJ502779. |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins. |
| Function | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
| Peptide Name | Chaperone Ric-8aSynembryn-A |
| Cellular Localisation | CytoplasmCell Cortex |
| Alternative Peptide Names | Chaperone Ric-8a proteinSynembryn-A proteinRIC8A protein |
Information sourced from Uniprot.org