RIC8A Positive Control for STJ502779 peptide (STJ505092)

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STJ505092-5
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Short Description :RIC8A Positive Control for STJ502779 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications:WB
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:WB: 1:250
Formulation:Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction:Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol:RIC8A
Gene ID:60626
Uniprot ID:RIC8A_HUMAN
Specificity:This is positive control is recommended for use in combination with RIC8A antibody STJ502779.
Post Translational Modifications Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins.
Function Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Peptide Name Chaperone Ric-8a
Synembryn-A
Cellular Localisation Cytoplasm
Cell Cortex
Alternative Peptide Names Chaperone Ric-8a protein
Synembryn-A protein
RIC8A protein

Information sourced from Uniprot.org

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