| Tissue Specificity | Found in the epidermis and esophageal epithelium. |
| Function | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. |
| Peptide Name | Inactive Rhomboid Protein 2Irhom2Rhomboid 5 Homolog 2Rhomboid Family Member 2Rhomboid Veinlet-Like Protein 5Rhomboid Veinlet-Like Protein 6 |
| Database Links | Reactome: R-HSA-9662834 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Peptide Names | Inactive Rhomboid Protein 2 proteinIrhom2 proteinRhomboid 5 Homolog 2 proteinRhomboid Family Member 2 proteinRhomboid Veinlet-Like Protein 5 proteinRhomboid Veinlet-Like Protein 6 proteinRHBDF2 proteinIRHOM2 proteinRHBDL5 proteinRHBDL6 protein |
Information sourced from Uniprot.org