Rat vHL (Von Hippel Lindau Tumor Suppressor) Sandwich ELISA Kit Ready-To-Use Kit (STJE0019427)

Rat vHL (Von Hippel Lindau Tumor Suppressor) Sandwich ELISA Kit Ready-To-Use Kit (STJE0019427)

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STJE0019427
£518.50 - £712.50
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.113ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This vHL Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Vhl
Gene ID: 24874
Uniprot ID: VHL_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
Protein Name Von Hippel-Lindau Disease Tumor Suppressor
Pvhl
Database Links Reactome: R-RNO-1234176
Reactome: -RNO-3232142
Reactome: -RNO-8951664
Reactome: -RNO-9706019
Reactome: -RNO-983168
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum
Nucleus
Found Predominantly In The Cytoplasm And With Less Amounts Nuclear Or Membrane-Associated
Colocalizes With Adrb2 At The Cell Membrane
Alternative ELISA Names Von Hippel-Lindau Disease Tumor Suppressor ELISA kit
Pvhl ELISA kit
Vhl ELISA kit
output

Information sourced from Uniprot.org

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