rat VEGFA protein (Recombinant) (His-Tag) (STJP018990)
SPECIFICATIONS
HostE.coli
ImmunogenRat
General Information
| Short Description | Recombinant-rat VEGFA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 50% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Vegfa |
| Gene ID | 83785 |
| Uniprot ID | VEGFA_RAT |
| Accession Number | NP_001274039 |
| Immunogen | Rat |
| Immunogen Region | 27-146aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMAPTTE GEQKAHEVVK FMDVYQRSYC RPIETLVDIF QEYPDEIEYI FKPSCVPLMR CAGCCNDEAL ECVPTSESNV TMQIMRIKPH QSQHIGEMSF LQHSRCECRP KKDRTKPEKC DKPRR |
Additional Info
| Tissue Specificity | Expressed in the pituitary, in brain, in particularly in supraoptic and paraventricular nuclei and the choroid plexus. Also found abundantly in the corpus luteum of the ovary and in kidney glomeruli. Expressed in the ductal epithelial cells of post-pubertal mammary glands. Expressed in the ductal and alveolar epithelial cells throughout the whole period of gestational evolution, lactation and involution. |
| Function | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor. |
| Protein Name | Vascular Endothelial Growth Factor AVegf-AVascular Permeability FactorVpf |
| Database Links | Reactome: R-RNO-114608Reactome: -RNO-194313Reactome: -RNO-195399Reactome: -RNO-4420097Reactome: -RNO-5218921 |
| Cellular Localisation | SecretedVegf-A120 Is Acidic And Freely SecretedVegf-A164 Is More BasicHas Heparin-Binding Properties AndAlthough A Significant Proportion Remains Cell-AssociatedMost Is Freely SecretedVegf-A188 Is Very BasicIt Is Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular MatrixAlthough It May Be Released As A Soluble Form By HeparinHeparinase Or Plasmin |
| Alternative Protein Names | Vascular Endothelial Growth Factor A proteinVegf-A proteinVascular Permeability Factor proteinVpf proteinVegfa proteinVegf protein |
Information sourced from Uniprot.org