| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 2.3pg/mL |
| Detection Limit: | 7.81-500pg/mL |
| Short Description : | This SPTAN1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Sptan1 |
| Gene ID: | 64159 |
| Uniprot ID: | SPTN1_RAT |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). |
| Post Translational Modifications | Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. |
| Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Protein Name | Spectrin Alpha Chain - Non-Erythrocytic 1Alpha-Ii SpectrinFodrin Alpha Chain |
| Database Links | Reactome: R-RNO-264870Reactome: -RNO-375165Reactome: -RNO-445095Reactome: -RNO-5673001Reactome: -RNO-6798695Reactome: -RNO-6807878Reactome: -RNO-9013420Reactome: -RNO-9013424 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexExpressed Along The Cell Membrane In Podocytes And Presumptive Tubule Cells During Glomerulogenesis And Is Expressed Along Lateral Cell Margins In Tubule Cells |
| Alternative ELISA Names | Spectrin Alpha Chain - Non-Erythrocytic 1 ELISA kitAlpha-Ii Spectrin ELISA kitFodrin Alpha Chain ELISA kitSptan1 ELISA kitSpna2 ELISA kitSpta2 ELISA kit |
| output |
Information sourced from Uniprot.org
