| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Rat SOCS3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Socs3 |
| Gene ID: | 89829 |
| Uniprot ID: | SOCS3_RAT |
| Immunogen Region: | Met1-Leu225 |
| Immunogen: | Rattus norvegicus (Rat) |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 3Socs-3Cytokine-Inducible Sh2 Protein 3 |
| Database Links | Reactome: R-RNO-1059683Reactome: -RNO-877300Reactome: -RNO-877312Reactome: -RNO-8849474Reactome: -RNO-8951664Reactome: -RNO-909733Reactome: -RNO-9705462Reactome: -RNO-983168 |
| Alternative Protein Names | Suppressor Of Cytokine Signaling 3 proteinSocs-3 proteinCytokine-Inducible Sh2 Protein 3 proteinSocs3 proteinCish3 protein |
Information sourced from Uniprot.org