Rat SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Kit (STJE0012258)

Rat SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Kit (STJE0012258)

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STJE0012258
£496.50 - £681.50
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This SOCS1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Socs1
Uniprot ID: SOCS1_RAT
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 1
Socs-1
Database Links
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative ELISA Names Suppressor Of Cytokine Signaling 1 ELISA kit
Socs-1 ELISA kit
Socs1 ELISA kit
output

Information sourced from Uniprot.org

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