Tissue Specificity | Kidney, in proximal tubule S1 segments. |
Post Translational Modifications | Glycosylated at a single site. |
Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity. Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney. |
Protein Name | Sodium/Glucose Cotransporter 2Na(+/Glucose Cotransporter 2Low Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 2 |
Database Links | Reactome: R-RNO-189200 |
Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
Alternative ELISA Names | Sodium/Glucose Cotransporter 2 ELISA kitNa(+/Glucose Cotransporter 2 ELISA kitLow Affinity Sodium-Glucose Cotransporter ELISA kitSolute Carrier Family 5 Member 2 ELISA kitSlc5a2 ELISA kitSglt2 ELISA kit |
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Information sourced from Uniprot.org