Tissue Specificity | Expressed in the involuting mammary gland, ovarian corpus luteum and prostate. In ovaries, low levels found in granulosa cells. High levels in corpora lutea of pregnant animals. |
Post Translational Modifications | |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. |
Protein Name | Secreted Frizzled-Related Protein 4Sfrp-4Ddc-4 Protein |
Database Links | |
Cellular Localisation | Secreted |
Alternative ELISA Names | Secreted Frizzled-Related Protein 4 ELISA kitSfrp-4 ELISA kitDdc-4 Protein ELISA kitSfrp4 ELISA kitDdc4 ELISA kitFrp ELISA kit |
output | |
Information sourced from Uniprot.org