| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. |
| Protein Name | Peroxiredoxin-1Hbp23Heme-Binding 23 Kda ProteinThioredoxin Peroxidase 2Thioredoxin-Dependent Peroxide Reductase 2Thioredoxin-Dependent Peroxiredoxin 1 |
| Database Links | Reactome: R-RNO-3299685Reactome: -RNO-5628897Reactome: -RNO-9818027 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Peroxiredoxin-1 ELISA kitHbp23 ELISA kitHeme-Binding 23 Kda Protein ELISA kitThioredoxin Peroxidase 2 ELISA kitThioredoxin-Dependent Peroxide Reductase 2 ELISA kitThioredoxin-Dependent Peroxiredoxin 1 ELISA kitPrdx1 ELISA kitTdpx2 ELISA kit |
| output | |
Information sourced from Uniprot.org
