| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.138ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This PPM1A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Ppm1a |
| Gene ID: | 24666 |
| Uniprot ID: | PPM1A_RAT |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | N-myristoylation is essential for the recognition of its substrates for dephosphorylation. |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Protein Name | Protein Phosphatase 1a Protein Phosphatase 2c Isoform Alpha Pp2c-Alpha Protein Phosphatase Ia |
| Database Links | Reactome: R-RNO-2173795 Reactome: -RNO-380972 |
| Cellular Localisation | Nucleus Cytoplasm Cytosol Membrane Lipid-Anchor Weakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization |
| Alternative ELISA Names | Protein Phosphatase 1a ELISA kit Protein Phosphatase 2c Isoform Alpha ELISA kit Pp2c-Alpha ELISA kit Protein Phosphatase Ia ELISA kit Ppm1a ELISA kit Pp2c1 ELISA kit Pppm1a ELISA kit |
| output |
Information sourced from Uniprot.org