| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 32.4pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description : | This OPTN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Optn |
| Gene ID: | 246294 |
| Uniprot ID: | OPTN_RAT |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. |
| Function | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR).regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. |
| Protein Name | Optineurin Fip-2-Like Protein |
| Database Links | Reactome: R-RNO-2565942 Reactome: -RNO-5205685 Reactome: -RNO-5357905 Reactome: -RNO-5357956 Reactome: -RNO-8854214 Reactome: -RNO-936964 Reactome: -RNO-9824878 |
| Cellular Localisation | Cytoplasm Perinuclear Region Golgi Apparatus Trans-Golgi Network Cytoplasmic Vesicle Autophagosome Recycling Endosome Found In The Perinuclear Region And Associates With The Golgi Apparatus Colocalizes With Myo6 And Rab8 At The Golgi Complex And In Vesicular Structures Close To The Plasma Membrane Localizes To Lc3-Positive Cytoplasmic Vesicles Upon Induction Of Autophagy |
| Alternative ELISA Names | Optineurin ELISA kit Fip-2-Like Protein ELISA kit Optn ELISA kit |
| output |
Information sourced from Uniprot.org