| Tissue Specificity | Expressed in NK cells. Present in lymph node, spleen and thymus (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Palmitoylation of Cys-27 and Cys-30 is required for raft targeting and efficient phosphorylation. Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation.which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. 'Lys-63'-linked ubiquitinated by TRAF6. |
| Function | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| Protein Name | Linker For Activation Of T-Cells Family Member 136 Kda Phosphotyrosine Adapter ProteinPp36P36-38 |
| Database Links | Reactome: R-RNO-114604Reactome: -RNO-202433Reactome: -RNO-2424491Reactome: -RNO-2454202Reactome: -RNO-2871796Reactome: -RNO-2871809Reactome: -RNO-5673001 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative ELISA Names | Linker For Activation Of T-Cells Family Member 1 ELISA kit36 Kda Phosphotyrosine Adapter Protein ELISA kitPp36 ELISA kitP36-38 ELISA kitLat ELISA kit |
| output | |
Information sourced from Uniprot.org
