Rat IREB2 (Iron Responsive Element Binding Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016437)

Rat IREB2 (Iron Responsive Element Binding Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016437)

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STJE0016437
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.108ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This IREB2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Ireb2
Gene ID: 64831
Uniprot ID: IREB2_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitously expressed in rat tissues, the highest amounts present in skeletal muscle and heart.
Post Translational Modifications Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.
Function RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Protein Name Iron-Responsive Element-Binding Protein 2
Ire-Bp 2
Iron Regulatory Protein 2
Irp2
Database Links Reactome: R-RNO-917937
Cellular Localisation Cytoplasm
Alternative ELISA Names Iron-Responsive Element-Binding Protein 2 ELISA kit
Ire-Bp 2 ELISA kit
Iron Regulatory Protein 2 ELISA kit
Irp2 ELISA kit
Ireb2 ELISA kit
Irp2 ELISA kit
output

Information sourced from Uniprot.org

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