| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Rat IL-1 receptor type II (CD121b)-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Gene Symbol: | Il1r2 |
| Gene ID: | 117022 |
| Uniprot ID: | IL1R2_RAT |
| Immunogen Region: | ECD |
| Immunogen: | Optimized DNA sequence encoding Rat extracellular domain of Rat IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells. NA |
| Post Translational Modifications | A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase. |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2 Il-1r-2 Il-1rt-2 Il-1rt2 Cd121 Antigen-Like Family Member B Il-1 Type Ii Receptor Interleukin-1 Receptor Beta Il-1r-Beta Interleukin-1 Receptor Type Ii Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form Mil-1r2 Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form Sil-1r2 Sil-1rii |
| Database Links | Reactome: R-RNO-9020702 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Cell Membrane Secreted |
| Alternative Protein Names | Interleukin-1 Receptor Type 2 protein Il-1r-2 protein Il-1rt-2 protein Il-1rt2 protein Cd121 Antigen-Like Family Member B protein Il-1 Type Ii Receptor protein Interleukin-1 Receptor Beta protein Il-1r-Beta protein Interleukin-1 Receptor Type Ii protein Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form protein Mil-1r2 protein Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form protein Sil-1r2 protein Sil-1rii protein Il1r2 protein Il-1r2 protein Il1rb protein |
Information sourced from Uniprot.org