Rat ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit (STJE0008705)

Rat ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit (STJE0008705)

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STJE0008705
£451.50 - £629.50
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Short Description :This ERRa Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates, cell lysates or other biological fluids..
Applications:ELISA
Reactivity:Rat
Sensitivity:0.053ng/mL
Detection Limit:0.156-10ng/mL
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Storage Instruction:Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:4.5 hrs
Gene Symbol:Esrra
Gene ID:293701
Uniprot ID:ERR1_RAT
Sample Type:tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name Steroid Hormone Receptor Err1
Estrogen-Related Receptor Alpha
Err-Alpha
Nuclear Receptor Subfamily 3 Group B Member 1
Database Links Reactome: R-RNO-383280
Cellular Localisation Nucleus
Cytoplasm
Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative ELISA Names Steroid Hormone Receptor Err1 ELISA kit
Estrogen-Related Receptor Alpha ELISA kit
Err-Alpha ELISA kit
Nuclear Receptor Subfamily 3 Group B Member 1 ELISA kit
Esrra ELISA kit
Nr3b1 ELISA kit
output

Information sourced from Uniprot.org

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