Rat DIO3 (Deiodinase, Iodothyronine, Type III) Sandwich ELISA Kit (STJE0008441)
SPECIFICATIONS
General Information
| Short Description | This DIO3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 0.117ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Dio3 |
| Gene ID | 29475 |
| Uniprot ID | IOD3_RAT |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Neonatal skin, placenta, skeletal muscle and cerebral cortex. |
| Post Translational Modifications | |
| Function | Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-diiodothyronine (3,3'-T2) to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD). Catalyzes the deiodination of 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2) via IRD. Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD). Catalyzes the tyrosyl ring deiodinations of T4AM (3,3',5,5'-tetraiodothyronamine), rT3AM (3,3',5'-triiodothyronamine), T3AM (3,5,3'-triiodothyronamine), 3,5-T2AM (3,5-diiodothyronamine), 3,3'-T2AM (3,3'-diiodothyronamine) and 3-T1AM (3-iodothyronamine). |
| Protein Name | Thyroxine 5-Deiodinase5diiiDioiiiType 3 DiType Iii Iodothyronine Deiodinase |
| Database Links | Reactome: R-RNO-350864 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEndosome Membrane |
| Alternative ELISA Names | Thyroxine 5-Deiodinase ELISA kit5diii ELISA kitDioiii ELISA kitType 3 Di ELISA kitType Iii Iodothyronine Deiodinase ELISA kitDio3 ELISA kitItdi3 ELISA kitTxdi3 ELISA kit |
| output |
Information sourced from Uniprot.org