| Tissue Specificity | Liver and kidney. |
| Post Translational Modifications | |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. |
| Protein Name | Carnitine O-Palmitoyltransferase 1 - Liver IsoformCpt1-LCarnitine O-Palmitoyltransferase I - Liver IsoformCpt ICpti-LCarnitine Palmitoyltransferase 1aSuccinyltransferase Cpt1a |
| Database Links | Reactome: R-RNO-200425Reactome: -RNO-5362517 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Carnitine O-Palmitoyltransferase 1 - Liver Isoform ELISA kitCpt1-L ELISA kitCarnitine O-Palmitoyltransferase I - Liver Isoform ELISA kitCpt I ELISA kitCpti-L ELISA kitCarnitine Palmitoyltransferase 1a ELISA kitSuccinyltransferase Cpt1a ELISA kitCpt1a ELISA kitCpt-1 ELISA kitCpt1 ELISA kit |
| output | |
Information sourced from Uniprot.org
