Rat CCL2/MCP-1 protein (Recombinant-Active) (C-His) (STJP011875)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenRattus norvegicus (Rat)
General Information
| Short Description | Recombinant-Active-Rat CCL2/MCP-1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to chemoattract mouse pro‑B cells (BaF3) transfected with human CCR2A. The ED50 for this effect is 30-150 ng/mL. |
Target Information
| Gene Symbol | Ccl2 |
| Gene ID | 24770 |
| Uniprot ID | CCL2_RAT |
| Immunogen | Rattus norvegicus (Rat) |
| Immunogen Region | Gln24-Asn148 |
Additional Info
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
| Protein Name | C-C Motif Chemokine 2Immediate-Early Serum-Responsive Protein JeMonocyte Chemoattractant Protein 1Monocyte Chemotactic Protein 1Mcp-1Small-Inducible Cytokine A2 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 proteinImmediate-Early Serum-Responsive Protein Je proteinMonocyte Chemoattractant Protein 1 proteinMonocyte Chemotactic Protein 1 proteinMcp-1 proteinSmall-Inducible Cytokine A2 proteinCcl2 proteinJe proteinMcp1 proteinScya2 protein |
Information sourced from Uniprot.org