Tissue Specificity | Expressed in the brain. |
Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
Protein Name | Renin ReceptorAtpase H(+-Transporting Lysosomal Accessory Protein 2Atpase H(+-Transporting Lysosomal-Interacting Protein 2Renin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment |
Database Links | Reactome: R-RNO-2022377Reactome: -RNO-6798695 |
Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCytoplasmic VesicleAutophagosome MembraneCell ProjectionDendritic Spine MembraneAxonEndosome MembraneClathrin-Coated Vesicle MembraneSecretory VesicleSynaptic Vesicle Membrane |
Alternative ELISA Names | Renin Receptor ELISA kitAtpase H(+-Transporting Lysosomal Accessory Protein 2 ELISA kitAtpase H(+-Transporting Lysosomal-Interacting Protein 2 ELISA kitRenin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment ELISA kitAtp6ap2 ELISA kitAtp6ip2 ELISA kit |
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Information sourced from Uniprot.org