Rat ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013774)

Rat ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013774)

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STJE0013774
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.122ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This ATP6AP2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Atp6ap2
Gene ID: 302526
Uniprot ID: RENR_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in the brain.
Post Translational Modifications Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments.
Function Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
Protein Name Renin Receptor
Atpase H(+-Transporting Lysosomal Accessory Protein 2
Atpase H(+-Transporting Lysosomal-Interacting Protein 2
Renin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment
Database Links Reactome: R-RNO-2022377
Reactome: -RNO-6798695
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Cell Projection
Dendritic Spine Membrane
Axon
Endosome Membrane
Clathrin-Coated Vesicle Membrane
Secretory Vesicle
Synaptic Vesicle Membrane
Alternative ELISA Names Renin Receptor ELISA kit
Atpase H(+-Transporting Lysosomal Accessory Protein 2 ELISA kit
Atpase H(+-Transporting Lysosomal-Interacting Protein 2 ELISA kit
Renin/Prorenin Receptor Cleaved Into - Renin Receptor Extracellular Fragment - Renin Receptor Cytoplasmic Fragment ELISA kit
Atp6ap2 ELISA kit
Atp6ip2 ELISA kit
output

Information sourced from Uniprot.org

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