Rat APPBP2 (Amyloid Beta Precursor Protein Binding Protein 2) Sandwich ELISA Kit (STJE0007274)
SPECIFICATIONS
General Information
| Short Description | This APPBP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 0.065ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Appbp2 |
| Gene ID | 303396 |
| Uniprot ID | APBP2_RAT |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface. |
| Protein Name | Amyloid Protein-Binding Protein 2Amyloid Beta Precursor Protein-Binding Protein 2App-Bp2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMembranePeripheral Membrane ProteinAssociated With Membranes And Microtubules |
| Alternative ELISA Names | Amyloid Protein-Binding Protein 2 ELISA kitAmyloid Beta Precursor Protein-Binding Protein 2 ELISA kitApp-Bp2 ELISA kitAppbp2 ELISA kit |
| output |
Information sourced from Uniprot.org