| Tissue Specificity | Brain specific. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4Adam-Ts 4Adam-Ts4Adamts-4Aggrecanase-1 |
| Database Links | Reactome: R-RNO-1474228Reactome: -RNO-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative ELISA Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ELISA kitAdam-Ts 4 ELISA kitAdam-Ts4 ELISA kitAdamts-4 ELISA kitAggrecanase-1 ELISA kitAdamts4 ELISA kit |
| output | |
Information sourced from Uniprot.org
