| Tissue Specificity | |
| Post Translational Modifications | Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. |
| Function | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. |
| Protein Name | Acetyl-Coa Acetyltransferase - MitochondrialAcetoacetyl-Coa Thiolase |
| Database Links | Reactome: R-RNO-70895Reactome: -RNO-77108Reactome: -RNO-77111Reactome: -RNO-9837999Reactome: -RNO-9854311 |
| Cellular Localisation | Mitochondrion |
| Alternative ELISA Names | Acetyl-Coa Acetyltransferase - Mitochondrial ELISA kitAcetoacetyl-Coa Thiolase ELISA kitAcat1 ELISA kit |
| output | |
Information sourced from Uniprot.org
