PTP alpha Blocking Peptide peptide (STJ505706)

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STJ505706-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PTP alpha Blocking Peptide is synthetically produced from the 650-700 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PTPRA
Gene ID: 5786
Uniprot ID: PTPRA_HUMAN
Immunogen Region: 650-700
Immunogen: Synthetic peptide taken within amino acid region 650-700 on human Receptor-type tyrosine-protein phosphatase Alpha protein.
Post Translational Modifications Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
Function Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.
Peptide Name Receptor-Type Tyrosine-Protein Phosphatase Alpha
Protein-Tyrosine Phosphatase Alpha
R-Ptp-Alpha
Database Links Reactome: R-HSA-375165
Reactome: R-HSA-5673001
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Peptide Names Receptor-Type Tyrosine-Protein Phosphatase Alpha protein
Protein-Tyrosine Phosphatase Alpha protein
R-Ptp-Alpha protein
PTPRA protein
PTPA protein
PTPRL2 protein

Information sourced from Uniprot.org

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