PTP alpha Blocking Peptide peptide (STJ505706)

SKU:
STJ505706-250
£326.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PTP alpha Blocking Peptide is synthetically produced from the 650-700 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PTPRA
Gene ID: 5786
Uniprot ID: PTPRA_HUMAN
Immunogen Region: 650-700
Immunogen: Synthetic peptide taken within amino acid region 650-700 on human Receptor-type tyrosine-protein phosphatase Alpha protein.
Post Translational Modifications Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
Function Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.
Peptide Name Receptor-Type Tyrosine-Protein Phosphatase Alpha
Protein-Tyrosine Phosphatase Alpha
R-Ptp-Alpha
Database Links Reactome: R-HSA-375165
Reactome: R-HSA-5673001
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Peptide Names Receptor-Type Tyrosine-Protein Phosphatase Alpha protein
Protein-Tyrosine Phosphatase Alpha protein
R-Ptp-Alpha protein
PTPRA protein
PTPA protein
PTPRL2 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ505707 PTP alpha Positive Control peptide (STJ505707) WB
STJ504664 PDE6 Alpha Blocking Peptide peptide (STJ504664) Immunodepletion/Immunocompetition
STJ505346 Inhibin alpha Blocking Peptide peptide (STJ505346) Immunodepletion/Immunocompetition
STJ504398 Alpha Synuclein Blocking Peptide peptide (STJ504398) Immunodepletion/Immunocompetition
STJ504946 Alpha SNAP Blocking Peptide peptide (STJ504946) Immunodepletion/Immunocompetition
!