Isotype Controls

Primary Antibodies

Isotype Controls

Isotype control antibodies are run alongside a primary antibody to check that a signal comes from specific binding, not background noise. Matched to the primary antibody's host species, isotype and conjugation, they act as a negative control, which matters most when studying weak or low abundance targets.

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About isotype controls Clonality
Product overview

What are isotype controls?

St John's Laboratory lists 877 isotype control antibodies, each used to confirm that a signal seen with a primary antibody reflects specific binding rather than background noise.

  • Matched to your primary antibody The isotype control usually matches the host species, isotype and conjugation of the primary antibody it is paired with.
  • Negative control function Measures the level of non-specific background signal that may come from use of the primary antibody.
  • Confirms specific binding Helps determine if an observed signal is due to specific binding of the primary antibody or non-specific binding, which is particularly important for weak or low abundance targets.
Clonality

Monoclonal and polyclonal options

The range is predominantly monoclonal, with a smaller polyclonal selection available.

Monoclonal (763) Polyclonal (108)

Need help choosing a matching isotype control?

Contact our technical support team for help selecting an isotype control that matches your primary antibody's host species, isotype and conjugation.

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